CASSS Discussion Group - November 2009

 

				2009 CASSS Award Dinner Join us for an evening honoring 2009 Scientific Acheivement Award Recipient: Dr. Jack Kirkland

Online registration is now closed.  Registrations will only be taken on-site now.

Award Lecture:
Superficially Porous Particles (SPP) for HPLC Columns: Then and Now

Since the paper on pellicular particles by Horvath and Lipsky in 1969, there has been interest in HPLC particles with a solid core and a porous outer shell. Although pellicular particles with a skin-like surface have seen rather limited use, superficially porous particles (SPP) with a much thicker porous shell have been of more interest because of much higher surface areas for solute interaction and the capability to vary the pore size to fit needs for separating molecules of different sizes. One of the first particles specifically designed for commercialization in HPLC was on the SSP model, although at that time in the late 1960's the particle diameter was about 35 μm. Due to the development of small, totally porous particles, commercial use of SSP was essentially missing for the next forty years, although a few studies have managed to keep the advantages of SPP in focus. Specifically, for larger molecules of poorer diffusion properties, the thin porous outer shell of SPP result in better kinetics (mass transfer) that allow faster separations at higher mobile phase velocities, compared to comparable-size totally porous particles. This advantage was especially demonstrated for protein and related separations when a 5 μm SPP with 30 nm pores was commercially introduced in 2001. More recently, smaller SPP (~2.7 μm) have been made available and these have created much interest in the HPLC community. A main reason for this interest is that some these materials have demonstrated separation efficiencies for small molecules that has not been previously seen, with reduced plate heights as low as 1.2 reported. As a result, these new ~2.7 μm SPP allow separations comparable to that for sub-2 μm particles but with only about one-half the operating pressure. New small SPP with larger pore sizes will allow very fast separations of larger molecules such as peptides because of their superior mass transfer properties. It appears that SPP now have a special place in HPLC and  continued growth of this technology is anticipated.

Schedule
5:30 - 5:45pm	Registration
5:45 - 6:30pm	Wine and Cheese Social Hour provided by Bay Bioanalytical Laboratory, Inc.
6:30 - 7:30pm	Dinner
7:30pm	Award Presentation & Lecture

Registration Prices	On or before Friday Nov. 6, 2009	On-Site
Industrial/Academic/Government- Lecture Only	$30	$35
Industrial/Academic/Government- Lecture and Dinner	$40	$55
Student/Post Docs- Lecture Only	$15	$20
Student/Post Docs- Lecture and Dinner	$25	$40

About the speaker:

After receiving A.B. and M.S. degrees in chemistry from Emory University in 1948 and 1949, respectively, Joseph (Jack) Kirkland worked for Hercules from 1949 50. He left to earn a Ph.D. in Analytical Chemistry at the University of Virginia in 1953. Jack was employed by E. I DuPont de Nemours Co. at the Experimental Station, Wilmington, DE, until 1992, when he retired as a DuPont Fellow. He then was a co founder of Rockland Technologies, Inc., where he was Vice President, Research and Development. This organization merged into the Hewlett Packard Co. in 1997, where he was Manager, Research and Development, Newport Site. Hewlett Packard created and spun off Agilent Technologies, Inc. in 2000, where Dr. Kirkland remained as Senior Scientist until his retirement in February, 2001. He joined Advanced Materials Technology in 2005 where he is Vice-President, R&D.

Dr. Kirkland is on the editorial advisory board of the Journal of Chromatographic Science  and a past member of the advisory board of the Journal of Chromatography. He edited the book, Modern Practice of Liquid Chromatography (1971), co authored Introduction to Modern Liquid Chromatography (1974), second edition, (1979), Modern Size Exclusion Liquid Chromatography (1979), and Practical HPLC Method Development (1988), second edition (1997). He was co professor of the American Chemical Society (ACS) Short Courses, Introduction to Modern Liquid Chromatography and Practical HPLC Method Development (1971- 1996), and co author of two taped ACS Audio Short Courses on liquid chromatography. Dr. Kirkland has authored over 140 major publications, mainly in the separation sciences, and holds twenty eight U. S. patents. Research interests involved high resolution separations, HPLC method development, silica chemistry and silane bonding reactions.

Dr. Kirkland received the 1972 American Chemical Society Award in Chromatography, the 1973 Delaware Section ACS Publication Award, the 1974 Dal Nogare Memorial Award in Chromatography from the Chromatography Forum of the Delaware Valley, the 1979 Anachern Award, the 1982 Torbern Bergman Medal in Analytical Chemistry from the Swedish Chemical Society, the 1988 Delaware Section ACS Award, the 1993  Eastern Analytical Symposium Award in Separation Science, DuPont's Lavoisier Medal in 1997, the A. J. P. Martin Chromatography Award Medal in 1997, and the 1999 Merit Award of the Chicago Chromatography Discussion Group. Dr. Kirkland was awarded the honorary D.Sc. degree by Emory University in 1974 and also was an Adjunct Professor of Chemistry at the University of Delaware.

 

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Special Thanks to the Event Program Partners:

Bay Bioanalytical Laboratory, Inc.
Bio-Rad Laboratories
LC Resources, Inc.

 

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About CASSS Discussion Groups:

CASSS Discussion Group Meetings are your opportunity to meet others who understand what you do, enjoy dinner and exchange new ideas.